High-fat Diet & Osteoporosis
Some claim that osteoporosis is due to a high-fat diet.
One study shows that BMD is lower in rats fed a high-fat diet.
Their explanation: "In vitro studies indicate that lipid products of oxidation promote osteoblastic differentiation of vascular cells and inhibit such differentiation in bone cells". (1) Osteoblasts are the cells that induce calcium absorption precipitation in the bones.
But the decrease in BMD can very well be due to a
decrease in physical activity. (The bones rapidly lose calcium in space due to inactivity
of the bones).
More importantly: Osteoporosis incidence does not correlate with average fat consumption per country. For example: Osteoporosis incidence within Europe is highest in Sweden (and Finland), significant higher than in countries like France, Italy and Greece, (2) but fat-consumption is much lower in Sweden and Finland.
Fat consumption in gram / capita / day, in 1998 (source FAO):
164.7 France 152.3 Italy 151.7 Greece
130.8 Finland 124.1 Sweden
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Sources (1) Parhami, F. et al, Role of lipids in osteoporosis. Arterioscler Thromb. Vasc. Biol. 2000 / 20 (11) / 2346-2348. (2) Lips, P. ,Epidemiology and predictors of fractures associated with osteoporosis. Am.J.Med. 1997 / 103 (2A) / 3S-8S / discussion 8S-11S. , Memon, A. et al, Incidence of hip fracture in Kuweit. Int. J. Epidemiol. 1998 / (5) / 860-865. , Paspati, I. et al, Hip fracture epidemiology in Greece during 1977-1992. Calcif. Tissue Int. 1998 / 62 (6) / 542-547. |